Can certain vitamins cause mouth ulcers?

43 messages in this subject.

My mom thinks that its vitamin C causing my mouth ulcers, but I have a feeling it's the multi one I take with D,A, and B in it along with the vitamin C. As I have taken a break from them for a week now, and the four ulcers I had are still there, one of them is even worse!
Fate 1 March 15
Well.. I found this page and thought I'd contribute.

I have been taking multivitamins for YEARS. Usually two, with a few fish oil, and a 2000iu vitamin D. I was preparing for a cruise and took a ton of vitamin C, with the other vitamins I took and guess what? TERRIBLE canker sore outbreak in my mouth the entire cruise and its still lingering 2 months later. I really think Vitamin C is causing this. Also, I am now not taking any multivitamins and no more vitamin D or C. Only fish oil. I will report back if these viscious canker sores clear up. This is a terrible way to live.
Ryan 9 February 15
Doug I have the same problem.. Dr. told me i was allergic to the compounds in the vitamins.. i've now given up and just don't take them any more and try to eat more better. Any knows of a vitamin that won't let me break in cold sores.. let me know! Thanks
Helen 17 January 15
I cannot take vitamin c either. When I was a toddler, I began getting cold sores. Our family dr told my mom to eliminate all juices for a month then add them back one at a time. They figured out that juices high in vitamin c caused the sores. The dr said that for whatever reason, my body does not utilize vitamin c and in fact, purges it from my body. I am 50 yrs old now and still cannot have vitamin c. I drank a glass of lemonade a couple of days ago and sure enough, now I have a cold sore. Even facial creams that contain vitamin c will cause a breakout. Other drs thru the years have said that my old family dr didn't know what he was talking about & that it's not the vitamin c but something else, but I know better. I have lived with this my whole life.
Amy 4 January 15
Been taking multivitamins for a while now, and continuously getting ulcers in my mouth and this is the first time ive discovered anything of the sort relating to this on the internet. Everyone keeps telling me that the correlation is all in my head, but its clearly not reading this!

Has anyone found a solution yet?!
EB 17 December 14
I have been taking a large number of supplements under a dr's recommendation for my general health and I AM feeling better - she instructed me to make my own liposomal vitamin C - which is a way to bind C with lethicin so it it's more absorbable. The first batch lasted about a week with one dose a day and I noticed I was getting mouth/lip ulcers. I used up the first batch and they cleared up but I wasn't paying great attention. I waited about 2 weeks and made another batch and almost immediately got the mouth and lip sores back. It's the Vitamin C without a doubt because even one day off clears them. I don't know if it's helping the rest of me to take it, but the mouth reaction isn't good. No more home chemist for me.
Esmeralda November 2014 18 November 14
Vitamin D needs magnesium, if you take a high dose vitamin D capsule then that will place a big demand on magnesium. Many people exist on an already low level of magnesium because of poor diet (you have to eat really healthily. Magnesium, along with calcium and zinc are supposed to prevent cold sores. My guess is the vitamin D creates a temporary blip in magnesium that gives the cold sore a chance to develop. It's probably the same when you take magnesium, the body notices the excess and starts using it. All speculation.
Mal 23 October 14
I get like a cut in the corner of my mouth that hurts when I open it and small cuts on the top,along my gums, and on the inside of my cheeks. I take a vitamin B complex and Vitamin D. I stopped taking both for a while when I ran out and the sores went away. A few days ago I started taking both again and the cuts are back. So now I have to stop taking 1 and see if the sores go away. If not I'll have to try the other. Since I'm vitamin D deficient I guess I'll stop the vitamin B complex and see how that goes.
jodi 26 August 14
I would like to further expand on this subject ..... I never take supplements or High fresh Orange Juice. Recently I had a severe cold so bought some real OJ with pulp and have been guzzling it ever since ... I have had a mouth full of ulcers and 3 back to back colds and I hardly ever get either. There is a link between all this and Vit C
Steve 27 July 14
Glad I found this board. Honestly for the past 2 years maybe a little longer I always felt a tingle come on the left of my tongue and a feeling like someone is pushing in the left of my throat. It got so annoying blood work came bak normal and no one can figure it out then last week I had the same feeling and the doctor said mouth ulcer back of throat left side tonsils. I don't have tonsils anymore but you know what mean. I drink a lot of booster juice after the gym and before that is high in vitamin C. And I think this is the cause. Not sure anyone else experiences left side of tongue numbness and left side under jaw uncomfortable feeling. But ya. Thanks
Dan 17 June 14
I've whittled it down to Vitamin C . I used to try and take Multivitamins , but no matter what brand , in a couple of days i'd develop ulcers on the inside of my cheeks, and on my tongue. As soon as I stop taking the supplements , they disappear . So I started to take different isolated vitamins in capsule form , and last week I started 500mg Vitamin C , and lo and behold ... I have 3 ulcers. Not sure if the effervescent stuff does the same thing . But will check it out.
Mike83 25 April 14
For me the culprit seems to be vitamin d or c. Now I just need to figure out which one. I will try to remember to post back here when I figure it out.
DLB 24 April 14
My family gets sores on our inner cheek after eating kiwi or grapefruit like fruits (high in Vit C).

They hurt and I use to chew them off. I just read tums or tea reduces the acid to speed healing. Aloe also cold help.
Amber 27 February 14
I workout and take a lot of different pills and get these sores/cuts on my tongue and inner lip that really hurts especially when eating. I'm gonna try and narrow it done on what it is. I take multivitamins, bcaa's, fish oils, fat burner etc
Chad 10 February 14
my mother and I also get blisters when taking vitamins. can it be the man made part of the pills?
can not eat 7 February 14
I have suffered with cold sores since I was young. I've have 4 cold sores back to back since I switched from centrum to gncs energy blend. I work out daily and take numerous supplements. I've narrowed it down to either a) multivitamins or b) yohimbe. I can't find any research or posts to back my yohimbe theory but I have luckily found this site. If anyone has any info that may prove beneficial, feel free to email me at
chris 15 January 14
It doesn't matter what supplement I take, I always get mouth ulcers. Very frustrating. I get restless legs and this is apparently due to low magnesium but I cannot take it for long enough to see if it makes a difference.
Michelle 31 October 13
I know the cause of my mouth ulcers when I get them, though for a long time I did not, since everyone (including Dr Weil) advocates taking Vit C for mouth ulcers. So when I first started to get them I INCREASED the dose @#%##@!! I started to realize that it was the Vit C CAUSING the problem. So after having about 8 in my mouth at one time I stopped the Vit C and slowly they cleared up. The only trouble is, most multivitamins contain quite a large dose, I can tolerate about 15mgms anything higher and I am in agony.
Patty 22 August 13
I am a 40 year old male. I too have noticed a link between taking multivitamins and small blisters appearing on my lips, which are very painful. They are more painful and more widely spread than cold sores I have otherwise had. The vitamins I take are Centrum Advance. I only take them when I am feeling otherwise rundown - then I get the mouth ulcers within 24 hours, so I stop again. I have repeated this three times, including once when I was feeling great and same problem every time. This is the first time I have found a website which takes about mouth ulcers or cold sores caused by vitamins. Every other site tells me I should take vitamins to get rid of the mouth ulcers. I have heard that either VitA or VitD could be an issue, as could Argenine used in the manufacture of the tablets.. Any other guesses? Easy solution is to stop vitamins - but I am low in Vitamin D as I have Colitis.
George 17 August 13
Denise - those capsules do stick readily, and if pulled off will remove some skin. Any sort of vitamins and supplements should be kept securely away from small children (and pets) just as you would prescription medicines.
Dom Walton 10 May 13
My 17 month old grandson developed blisters inside his upper lip and tongue. I found one of my husbands B Complex gel caps by his highchair on the floor. It did not have bite marks in it but I began to suspect that this may be the reason for the blisters. I'm sure that if he put it in his mouth that he spit it back out right away because of the foul taste but maybe it was in there long enough to cause the blisters.
Denise 10 May 13
My 12 year old son has just been given Vitamin D medicine by a Paedatrician. He now has the most horrendously painful mouth ulcers, is it the Vitamin D.
Deborah Deane 20 April 13
Add me to the list. I just added Calcium to my vitamins (I take D, Generic Multi Vit Fish Oil) and almost immediately had the mouth blisters. mostly on my tongue. They'd clear up and the very next day a new one would form.

I've been taking the others for quite a while with no problems.

Dixie 10 April 13
I suspect the higher dose of B complex vitamins set off ulcers in my mouth & on my lips & in my throat. Prior to the large oral dose,I had been taking a monthly shot to which I never reacted. The ulcerations are large & they're painful.
Cindy Coletti 8 April 13
About how long does it take for the ulcers to go away once you stop taking the vitamins?
This really hurts, and it is hard to talk! And that is a problem for me since I am a big talker. Guess I am giving everyone a rest
Pamela 2 March 13
I have been dieting and thought it would be smart to start taking a multivitamin. About 2 weeks ago I started getting sores on the right inside of my mouth. I thought I might have bitten myself. THey got worse. Then the other side. Burning has been so bad. I thought did I do pr eat anything different. Well Ihurt so bad tonight. I sat down at the computer..and there they were. What I had started to do different 2 weeks ago. The multivitamin. I entered vitiamin allergies on the computer...and there you were. Thanks. I hate to say I am glad I am not alone. But at least we all have found our answers.
Pamela 28 February 13
Well i've been off and on with the B group vitamins for years because i'm not sure if they contribute to my ongoing migranes or not but if I don't take them then I soon become flat and tired, and yes there does seem to be a link from the time I restart the vitamin B and the return of my mouth ulcers and yet I just read on another site that a lack of vitamin B12 may be the reason for the mouth ulcers so now i'm just confused.
Abel 27 February 13
Hallelujah!!! I've suffered from this problem for years and so relieved to hear there are similar cases out there! Various doctors could not provide an explanation, they simply told me to stop taking the multivitamin citing they are a money making scheme in any case. That simply isnt a I need to find a brand that is not harsh on my body? Any suggestions?
Lands 8 February 13
I started taking Centrum Silver and noticed that I started getting severe mouth ulcers. It took me awhile to figure out that my ulcers stated at the same time I started taking the vitamin supplements. I tried mouth wash, an oral topical medications that my dentist prescribed, peroxide,etc...but nothing worked. I stopped taking them 3 days ago and my mouth feels almost normal. There needs to be some record that vitamin supplements can possibly cause mouth ulcers. January 13, 2013
Chuck 14 January 13
For the past 2 weeks I have been taking B Complex (expensive brand) and I have been in agony with mouth ulcers. I do believe there is a link between the two, so I have now stopped and hoping that they will clear up.
Does anyone know why B Complex causes mouth ulcers?
LH 13 January 13
I too am having this issue. I started 3 days ago taking many different vitamins and omega3, I have gotten very small sores on the edge of my lips and a few inside my mouth, this is very discouraging but somewhat relieved to know I'm not the only one.
Lisa 19 October 12
Yes, I too have observed over the years that whenever I begin to take multivitamin or even B-complex I get mouth sores or mouth ulcers or fever blisters. Sometimes inside my mouth, sometimes at the edge of my lips. It was thoughtful for me when I discovered this phenomenonal connection between vitamin intake and fever blisters/mouth sores. Before I would immediately stop the vitamin intake after the observation. But today I'm begining to feel like it may not be a bad thing so instead of stopping I just go ahead and double up on my vitamin intake. But what I'm not too sure is if I would get same immediate reaction by consuming an extremely excessive amount of fruits and natural foods-containing vitamins. Though it might be difficult to get an increased amount of vitamins within a short time by eating fruits no matter what quantity.
KC 8 October 12
I have exactly the same problem, took me a while to figure out what it was but it is definitely the multivitamins, i have now just expanded my diet to get all the vitamins and minerals i need, so much better
ted 2 August 12
I have been taking a calcium and magnesium supplement in a high dose a week before my mentsral cycle to help with PMS. good news is PMS is much improved. bad news is mouth and tongue are really bothering me. wondering which is worse.
Annelise 17 June 12
I too have mouth ulcers with multivitamins. Started GNC men's multivitamin and within 2 days developed ulcers. It has been two weeks with no improvement. I have read Vit C can cause mouth ulcers but cannot confirm. This Sucks.

My 18 April 12
What a relief to hear that so many others like me have been expereiencing the problem of mouth ulcer on vitamin supplements. Surprisingly this has developed in the recent past (that is last 6 months). Earlier the same vitamins I was taking without any problem. I am 48 yr old female and I wonder ???? if it is anyway related to the changes during menopause.....
Mythili 16 April 12
I am so glad I google and am not alone. I am on day 2 of a multivitamin and have noticed a lot of small sores on my tongue and the roof of my mouth. This is the first time I've experienced this, but I bought Kroger brand because they weren't so expensive. I'd like to know what vitamin is causing this. Thanks!
Belle 28 March 12
Still dont know what causes it whether its an overdose of a mineral or vitamin ( in the 100% RDA varieties) but I cant take sainsburys A-Z multivitamin/minerals-if I do within a week Ive got my tongue ulcer back. I am now taking a different less than 100% RDA supplement.
Lechef 13 March 12
i too experience the same problem. i checked internet for people with similar problem and this is the only page i encountered... i noticed that when i take multivitamins i also seem to have mouth sores.. does anyone know what exactly is causing this?
Emmanuel 12 March 12
I'm a 48 year old female and I too believe the vitamins are giving me mouth ulcers. Every time I try to take calcium, I'd get mouth ulcers so I'd stop. Just recently I purchased from GNC a Womens Ultra Mega suppliment for energy and metabolish. When I started developing the mouth ulcers, I figured it was just the normal reaction to something new in my body and thought I'd ride it out hoping they go away. It's been 2 weeks and I'm not sure it's worth it. GNC does offer a 30 day money back guarantee. I'm planning to revisit the store this week.
CheerMOM 17 February 12
I am trying some other alternatives supplements at present too. You can actually buy hypoallergenic vitamins in my health shop but they are very very expensive.
Lechef 15 March 11
I have noticed increased random out breaks of mouth/tongue ulcers as a result of prolong usage of cheap multivitamins. Once i stop, the ulcers do not reappear for months. I don't know if it is the vitamins or not but i am on a 2 month cycle right now experimenting.
Ste 14 March 11
For years I have noticed certain multivitamins cause me mouth ulcers. Does anyone know why that is?
I have been told the cheaper vitamins can do that due to the way they are manufactured. Another possibility I am told is that my body is getting something it does not need and it is rejecting it or there is a reaction. I just did a comparison between some a multivitamin that does not bother me and ones that do give me the ulcers. Seems like the ones that give me the ulcers contain Iron, Potassium, Boron, Phosphorus, Chloride, and Coenzyme. Does anyone know if these items are known problems to some people?

I have been dealing with this for 20 years or better and would like to know the answer to what is causing the ulcers. There is no doubt it is due to certain multivitamins.
Doug 10 January 11

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Can certain vitamins cause mouth ulcers?

43 messages in this subject.